Use Caution/Monitor. Potential for additive CNS stimulation. Most methylphenidate will decrease the level or effect of valsartan by pharmacodynamic antagonism. A: Generally acceptable. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. benzphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. promethazine, methylphenidate. Dosing recommendations are based on current dose regimen and clinical judgment. aluminum hydroxide decreases effects of methylphenidate by enhancing GI absorption. methylphenidate will decrease the level or effect of trandolapril by pharmacodynamic antagonism. Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. only.fluphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Contraindicated. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Other (see comment). Conversion dosage should not exceed 72 mg daily. Use Caution/Monitor. Risk of acute hypertensive episode. Use Caution/Monitor. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Risk of acute hypertensive episode. Applies only to oral form of both agents. However, people can also use nonstimulant drugs . Contraindicated (1)tranylcypromine increases effects of methylphenidate by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Use Caution/Monitor. Risk of acute hypertensive episode. Potential for additive CNS stimulation. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor BP. doxapram increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. arformoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Minor/Significance Unknown. chlorpromazine, methylphenidate. methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. epinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. If you log out, you will be required to enter your username and password the next time you visit. Other (see comment). only. Use Caution/Monitor. Monitor Closely (1)quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Risk of acute hypertensive episode. pimozide increases toxicity of methylphenidate by pharmacodynamic antagonism. Other (see comment). Monitor Closely (1)methylphenidate will increase the level or effect of atomoxetine by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Minor (1)amantadine, methylphenidate. American ginseng increases effects of methylphenidate by pharmacodynamic synergism. Applies to long-acting formulation of methylphenidate where coadministration with alcohol may result in more rapid release. Use Caution/Monitor. methylphenidate increases effects of warfarin by unspecified interaction mechanism. Methylphenidate may diminish antihypertensive effects. Applies only to oral form of both agents. amitriptyline, methylphenidate. methylphenidate will decrease the level or effect of nisoldipine by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of felodipine by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Applies only to oral form of both agents. Use Caution/Monitor. lofepramine, methylphenidate. Avoid or Use Alternate Drug. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Methylphenidate may diminish antihypertensive effects. Interaction more likely in certain predisposed pts. Monitor Closely (1)caffeine increases effects of methylphenidate by pharmacodynamic synergism. Additive vasospasm; risk of hypertension. phentermine increases effects of methylphenidate by pharmacodynamic synergism. Minor (1)American ginseng increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Ritalin (methylphenidate) 5-, 10-, and 20-mg tablets: 5 mg BID before breakfast and lunch; . Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg. Risk of acute hypertensive episode. Applies only to oral form of both agents. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Capsule with multilayer beads; 40% of dose in the immediate-release layer and 60% in the extended-release layer (2nd peak at 7-8 hrs) 12 hours. Use Caution/Monitor. Use Caution/Monitor. Adults20 to 30 milligrams (mg) given in divided doses 2 or 3 times a day, taken 30 to 45 minutes before meals. Monitor Closely (1)ephedrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor BP. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Applies only to oral form of both agents. Use Caution/Monitor. Risk of acute hypertensive episode. only. Use Caution/Monitor. Monitor Closely (1)methylphenidate will increase the level or effect of phenytoin by unknown mechanism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Contraindicated. Some patients report a more abrupt onset and offset with Ritalin . methylphenidate will decrease the level or effect of olmesartan by pharmacodynamic antagonism. benzhydrocodone/acetaminophen, methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of azilsartan by pharmacodynamic antagonism. Concerta and Ritalin share the same active ingredient. Other (see comment). perphenazine, methylphenidate. esketamine intranasal, methylphenidate. Monitor BP. Potential for additive CNS stimulation. Monitor Closely (2)famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Risk of acute hypertensive episode. ozanimod increases toxicity of methylphenidate by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor BP. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Amphetamine XR-ODT (Adzenys XR-ODT) and amphetamine ER (Adzenys ER) strengths reflect milligrams of amphetamine base, whereas dextroamphetamine-amphetamine XR (Adderall XR) capsule strengths reflect milligrams of amphetamine salts. Contraindicated. Contraindicated. Monitor Closely (2)trifluoperazine, methylphenidate. Monitor BP. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. This drug is available at a higher level co-pay. Use Caution/Monitor. methylphenidate will decrease the level or effect of losartan by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Modify Therapy/Monitor Closely. Additive vasospasm; risk of hypertension. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. thioridazine, methylphenidate. only.trifluoperazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)green tea, methylphenidate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor BP. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Methylphenidate may diminish antihypertensive effects. only. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. fluphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Applies only to oral form of both agents. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. Use Caution/Monitor. only. ergoloid mesylates, methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)methylphenidate will decrease the level or effect of nadolol by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)lisdexamfetamine increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. Methylphenidate may diminish antihypertensive effects. serdexmethylphenidate/dexmethylphenidate and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. sodium zirconium cyclosilicate will increase the level or effect of methylphenidate by increasing gastric pH. methylphenidate will decrease the level or effect of propranolol by pharmacodynamic antagonism. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Applies only to oral form of both agents. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Risk of acute hypertensive episode. Use Caution/Monitor. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Monitor BP. Applies only to oral form of both agents. methylphenidate will decrease the level or effect of nifedipine by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. aripiprazole increases toxicity of methylphenidate by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor. Risk of acute hypertensive episode. Mechanism: unknown. Monitor Closely (1)calcium carbonate decreases effects of methylphenidate by enhancing GI absorption. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)metaproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contraindicated. Methylphenidate may diminish antihypertensive effects. informational and educational purposes only. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of amlodipine by pharmacodynamic antagonism. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. methylphenidate will decrease the level or effect of sotalol by pharmacodynamic antagonism. Monitor BP. Interaction more likely in certain predisposed pts. prochlorperazine, methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Risk of acute hypertensive episode. Monitor Closely (1)methylphenidate will decrease the level or effect of felodipine by pharmacodynamic antagonism. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Applies only to extended release formulation. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. Contraindicated. Monitor Closely (1)ziprasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. yohimbe, methylphenidate. Applies only to oral form of both agents. Either increases effects of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Methylphenidate may diminish antihypertensive effects. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. Minor (1)guarana increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Use Caution/Monitor. 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