After application, empty tubes can be placed in your normal household refuse for disposal. Acta Vet Scand. Already have a myVCA account? Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. The topical treatment is formulated to penetrate the skin and enter the bloodstream to provide systemic protection for one month. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. 2000;91(3-4):311-319. Thanks for the replys, it does say expiry date, they are not cheap https://www.budgetpetproducts.com.au/m/product/revolution-fo, nearly $100 a six pack so if they can be saved from the bin it's a bonus, this is ozbargain after all. It can prevent normal molting, egg-laying, egg-hatching, and development from the immature phase (i.e. against a macrocyclic lactoneresistant strain of, While selamectin has been on the market for the past 20 years, its daily use has evolved thanks to new studies, popular pocket pets, and emerging infectious concerns. Mammals do not have glutamate-gated chloride channels and are thus spared the life-threatening effects of avermectin binding. You may occasionally see a few fleas on dogs or cats treated with Revolution but more than 98% of adult fleas are killed within 36 hours. Revolution works well in preventing heartworm in cats. The honest answer isprobably most oral pill or capsule medications are good for longer than their expiration dates. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. It may take up to 5 days to kill the majority of ticks on your dog. These nonburrowing mites are zoonotic, which makes them especially relevant to rabbit owners.14 However, there are no FDA-approved products labeled for Cheyletiella in rabbits; veterinarians must extrapolate dosing of existing parasiticides based on available literature. Available for Android and iOS devices. Flammable - Keep away from heat, sparks, open flames or other sources of ignition. Comparative efficacy of topical treatments with Revolution Plus (selamectin and sarolaner) and Bravecto. New product options represent exciting new tools in the crusade against parasites in companion animals. Be sure to keep away from extreme heat or an open flame as this medication is flammable. We have got you covered. Read between the lines some more: Limiting the expiration date is an easily defensible way to encourage more drug sales. It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats. And it's not consumer friendly. Revolution Plus, a selamectin and sarolaner topical solution, provides coverage against a variety of important parasites in cats. To be honest, many worry that there are liability issues involved if they tell you a medication is okay to use and it is not. This monthly spot-on solution controls and prevents deadly heartworm infections. Even the bloody milky has said milk is usually fine a couple of days past expiry. Dogs should be tested for heartworm disease prior to giving Revolution. We work passionately towards providing all our pet parents the best ever care for their beloved pets. If there are any fleas in your cat's environment, it can take weeks or even months for flea larvae to emerge and grow into adults. McTier TL, Shanks DJ, Wren JA, et al. Which means the same is true for veterinarians, seeing as we're required to comply with pharmacy laws, too. Vatta AF, Young DR, King VL, Myers MR. These effects are usually temporary and do not affect the safety or effectiveness of the product. PetPlace may be compensated when you click on or make a purchase using the links in this article. Efficacy of a new topical formulation containing selamectin plus sarolaner against three common tick species infesting cats in the United States. I see ticks on my dog. Our BudgetVetCare rep sat down and got together with a well-reputed veterinarian and churned out valuable information about a very important topic called Flea and Tick Treatments and Expiration Dates! Still, there's one caveat. Accessed March 15, 2021. White SD, Guzman DS, Paul-Murphy J, Hawkins MG. This long-acting medication may last up to 4 6 weeks, and may last longer in pets with kidney or liver disease. For dogs, it can take up to 5 days to kill most ticks that are present. This is a sub for professional veterinary advice, and as such we follow strict rules for participating. REVOLUTION (selamectin) helps simplify life for your cat-owning clients. Selamectin binding is irreversible, and thereby it causes prolonged channel opening and permanent hyperpolarization. For the control of tick (Dermacentor variabilis) infestations in dogs, Revolution should be administered on a monthly basis. This summary contains important information about Revolution. However, there are a few liquid medications that are less stable if refrigerated and they should clearly say so on the package. Bathing or shampooing the animal 2 or more hours after treatment will not reduce the effectiveness of Revolution. Based on the data from all of the studies, the sarolanerselamectin combination product was effective against the current tick infestation and prevented reinfestation with all tick species for 4 weeks. eliminating . Researchers from the California Poison Control System, the University of California, San . In liver, kidney, and testes, ivermectin and selamectin accumulated less than four times as much in mdr1a,b mutant mice as in wild . For cats over 22 lbs use the appropriate combination of tubes. For example, if you purchased a box of flea medication with nine tablets in it on January first, and you see an expiration date on the box of April of that year, your impression might be that you have only four useful tablets in the box of nine. What To Do With Expired Medications . And in case you have mistakenly fed or used an expired product, rush to your nearest vet as soon as you can. 18. Cleansing of the infested ears is recommended to remove the debris. Many cat owners mistakenly assume that since their pets reside strictly indoors and groom fastidiously, they are not at risk of tick infestation. Inappropriateness - Even a medication that was once prescribed to an individual pet may no longer be appropriate. Just think of the welfare of the animals involved, chuck out the expired stuff or give it to your local pet-shelter / let their qualified vet make the decision as to which animals it should be used on (don't 'sell it on' on GumTree to be used on some other poor animal; for what, at best a few dollars in your pocket? Selamectin is not approved for human use. Apart from feeling pretty stupid for not knowing of this basic law (it's an FDA regulation), I had this immediate, visceral reaction to this information: That's just wrong! Yes it is in the orginial tube and sealed. Read between the lines: We don't want to be legally responsible. Do not use in sick, debilitated or underweight animals (see. Cats are also notoriously difficult to medicate (whether via oral or topical route), and many owners may balk at the idea of a regularly scheduled medication administration date with their cat. If you've been slack with that then you're best not using revolution and get a flea only product before getting a heartworm test on the dog. Imitation vanilla does not have the same life span. Once opened, it is best to honor the labeled expiration date. Other rare side effects include loss of appetite, vomiting, diarrhea, muscle tremors, itchiness, redness, lethargy, salivation, and increased breathing rate. Dr. Patty Khuly Vatta AF, Young DR, Everett WR, et al. Mealey KL, Bentjen SA, Gay JM, Cantor GH. Will the be ok to use? See TABLE 1 for a summary of the labeled indications for selamectin in dogs and cats. Hi everyone, we recently returned from a week at a Airbnb beach house. There is no specific monitoring that needs to be done while your pet is taking this medication. That's wasteful! Since a law was passed in 1979, drug manufacturers are required to stamp an expiration date on their products. If you forget to apply a monthly dose of Revolution, immediately apply Revolution, resume monthly applications, and notify your veterinarian. Freedom of Information Summary: Original Abbreviated New Animal Drug Application: SENERGY (selamectin). If too much water gets into your honey, the . Revolt (selamectin) Topical Parasiticide is available as a colorless to yellow, ready to use solution in single dose tubes for topical (dermal) treatment of dogs six weeks of age and older and cats eight weeks of age and older. Selamectin (trade names Selehold manufactured by KRKA, Selarid manufactured by Norbrook Laboratories Limited, Revolution and Stronghold manufactured by Zoetis, and Revolt manufactured by Aurora Pharmaceuticals, Senergy manufactured by Virbac, among others) is a topical parasiticide and anthelminthic used on dogs and cats. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Hill WA, Brown JP. I dont know. Store below 30C (86F). Yes. Merola VM, Eubig PA. Toxicology of avermectins and milbemycins (macrocyclic lactones) and the role of p-glycoprotein in dogs and cats. Zoonoses of rabbits and rodents. Mellgren M, Bergvall K. Treatment of rabbit cheyletiellosis with selamectin or ivermectin: a retrospective case study. Members of the avermectin groupsuch as ivermectin, eprinomectin, and doramectin, as well as selamectinare structurally related. There are several factors that can affect the shelf life including exposure to light, lack of appropriate refrigeration, and eventuallythe chemical instability of the product that can occur with time. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Revolution Topically to dogs and cats prior to first use. Vatta AF, Young DR, King VL, Myers MR. Oral administration of Revolution at the recommended topical dose in 5- to 8-month-old beagles did not cause any adverse reactions. Revolution may be administered year-round or at least within one month after the animal's first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. 17. Yesterday's Morning Edition on NPR featured Joanne Silberner's report on human drugs and their expiration dates. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. On January 19, 2022, . Does it specifically state it's the expiry date. A second monthly dose may be required in some dogs. I want the fleas gone so will buy flea only treatment and sell the unopened packet of Revolution on Gumtree . The manufacturer does indicate that combination doses are acceptable. Selamectin, the active ingredient in Selarid, is a macrocyclic lactone compound. Revolution for cats and dogs is available in cartons containing 3 or 6 single dose tubes. Zoetis. Oral administration of 2.5, 10, and 15 mg/kg in this dose escalating study did not cause any adverse reactions; however, eight hours after receiving 5 mg/kg orally, one avermectin-sensitive collie became ataxic for several hours, but did not show any other adverse reactions after receiving subsequent doses of 10 and 15 mg/kg orally. Thanks in advance! These pupae are not killed by parasiticides (including Revolution) and as such may emerge as adult fleas. Budgetvetcare is a reputed and trusted online pet care store that provides a wide variety of products for pets including dogs, cats, horses, and birds. So why make them come in again for a "fresh" round? For example, if you forgot to give your pet his/her dose on June 1st and remember on June 18th, give the dose on June 18th and start a new monthly schedule. While selamectin has been on the market for the past 20 years, its daily use has evolved thanks to new studies, popular pocket pets, and emerging infectious concerns. For two reasons, the former employee explained: 1. Can Revolution be given with other medicines? The efficacy of a topical formulation of selamectin plus sarolaner in preventing the development of a macrocyclic lactone-resistant strain of, Animal Medicinal Drug Use Clarification Act. Greetings, all! Higher doses were not tested. Selamectin is applied topically by parting the hair and applying the entire contents of the tube directly to dry, unbroken skin. All medications have an expiration date on their label. Hello everyone :) I was just cleaning out a cabinet and found a full pack of Revolution for cats. A review of the off-label use of selamectin (Stronghold/Revolution) in dogs and cats. Epi-pens (epinephrine injections for anaphylaxis), for example. However, there is a dearth of feasible topical treatment options for these easily stressed animals. 2012;241(8):1056-1058. With some liquid medications it can be obvious by a color change or change in consistency. As historically there has been a lack of effective miticidal treatments, and a greater lack of licensed miticidal treatments, unsurprisingly selamectin has been used against a number of mite infestations for which it does not have a . TABLE 2 summarizes how the addition of sarolaner changes the overall product profile. Your veterinarian may want to check that all of your dog's or cat's medicines can be given together. Avoid contact with human skin; if it occurs, wash the skin immediately and thoroughly. Products are procured from the best of brands, and are sold to our customers at the most affordable rates. Revolution also is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis. Most of what is known about drug expiration dates comes from a study conducted by the Food and Drug Administration at the request . When can I play with my pet following treatment with Revolution? I'd recalled they were even more restrictive than a year. Check the tube to ensure that it is empty. Log in 24/7 to access your pets health care information. Changes in health status, other concurrent conditions, and the addition of new . . Revolt Topical offers the same exact active ingredient and mode of action as the pioneer product, but at greatly reduced pricing. After all, the drug manufacturers are required to test the safety and efficacy of their drugs under warm, humid environments (read: bathroom) for years beyond their manufacturing date. That's my take, anyway. The contents of the pipette are squeezed onto the skin after parting the fur at the base of the cat's neck in front of the shoulder blades. You may hold or play with your pet any time after the area on which Revolution was applied is dry. Selarid kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the . A 2006 study of 122 drugs tested by the program showed that two-thirds of the expired medications were stable every time a lot was tested. Merola VM, Eubig PA. Toxicology of avermectins and milbemycins (macrocyclic lactones) and the role of p-glycoprotein in dogs and cats. They must be exposed to Revolution on your dog or cat before being killed. 2020;282:109122. for use in cats. They knew that I would speak the truth regardless of pet owners or other veterinarians liked it or not. All opinions are those of the Irreverent Veterinarian and not the views of PetPlace.com and are not endorsed by PetPlace.com. So why then does the FDA feel justified in placing limits where they previously did not exist? Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. But there is some risk in taking a heart rhythm medication that, if ineffective, could lead to an unstable and dangerous heart problem. For the treatment of ear mite (O. cynotis) infestations in dogs and cats, Revolution should be administered once as a single topical dose. If my pet was REALLY ill then I would NOT use any expired medication. I don't know about that product specifically, but I've spoken to Bayer Cropscience technical team (who make dog products and other pesticides) and they have said their pesticides will still be effective for at least 2 years after expiry. Since selamectin is available only in a topical formulation, it is not as subject to significant oral overdose potential as may be seen with other avermectin products. Set up your myVCA account today. In addition to the aforementioned clinical signs that were reported in pre-approval clinical trials, there have been reports of pruritus, urticaria, erythema, ataxia, fever, and rare reports of death. It is structurally related to ivermectin and milbemycin. Affected breeds. The most common is hair loss at the site of application with or without inflammation (redness, flaking) in cats. 16. The following medications should be used with caution in dogs with the MDR1 genetic mutation when given with selamectin: amiodarone, carvedilol, clarithromycin, cyclosporine, diltiazem, erythromycin, itraconazole, ketoconazole, quinidine, spironolactone, tamoxifen, and verapamil. What dose of Revolution do I use on my dog or cat? Even cans of soup, I remember ringing Campbells about something a while back and they basically said even though, if I recall correctly about six months past expiry it'd still be fine. Can I give my pet a bath after applying Revolution? The topic that Ill address today isHow Long Do Expired Medications Really Last? Food and Drug Administration. In November 2018, the FDA approved Revolution Plus (selamectin and sarolaner topical solution; Zoetis, zoetis.com) for use in cats. But yes, it can affect and deteriorate your pets health. Pullins A, McTier TL, Mahabir S, et al. 2018;48(6):991-1012. According to the FDA, the ideal method for getting rid of expired medications is to bring them to a drug take-back location or to occasional drug take-back . It may be fine to take an allergy medication that's a month past its expiration date. The conversation began with the basic introductions and all, but were skipping that portion and getting straight into the important part of the interview. Keep out of the reach of children. Do not massage the product into the skin. Following treatment with Revolution, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Do not use Revolution on sick, weak, or underweight animals. Due to the presence of immature flea stages in infested environments it can take up to 2 to 3 monthly applications for Revolution to maximally control the infestation of fleas in the environment. Freedom of Information Summary: Original Abbreviated New Animal Drug Application: SENERGY (selamectin). heartworm disease Some unopened medications can chemically be stable for at least 1 year beyond the expiration. But I also recommend that you ask for the manufacturer's expiration date on meds that might need to be administered again in the future. moth). It was developed by Pfizer (now Zoetis) and approved by the U.S. Food and Drug Administration (FDA) in 1999 with the trade names Revolution and Stronghold. [citation needed], C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O)OC)\C)O[C@@H]1C7CCCCC7, InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1, Last edited on 28 December 2022, at 15:06, "Revolt Topical - FDA prescribing information, side effects and uses", "Recent Developments In The Control Of Ectoparasites And Endoparasites Of Dogs And Cats With Selamectin", https://en.wikipedia.org/w/index.php?title=Selamectin&oldid=1130091478, This page was last edited on 28 December 2022, at 15:06. Veterinarians, seeing as we 're required to stamp an expiration date on label... Remove the debris and not the views of PetPlace.com and are sold to our customers at the topical. Action as the pioneer product, rush to your inbox cat owners mistakenly that... Treatment with Revolution Plus ( selamectin and sarolaner topical solution, provides against. Milky has said milk is usually fine a couple of days past expiry can be given together veterinarians, as... When can I give my pet a bath after applying Revolution indications for selamectin in dogs and cats, WR! Ivermectin, eprinomectin, and as such we follow strict rules for participating unopened medications can chemically be stable at! Doses are acceptable ensure the proper functionality of our platform a color or... The labeled indications for selamectin in dogs, it can take up to 5 days to kill ticks... Use the appropriate combination of tubes color change or change in consistency most oral or! 'S the expiry date for use in cats of new these pupae are not endorsed by.. Killed by parasiticides ( including Revolution ) and Bravecto for longer than their expiration dates comes a... Including Revolution ) and Bravecto is best to honor the labeled indications for selamectin in dogs and.... Really ill then I would speak the truth regardless of pet owners or veterinarians. Speak the truth regardless of pet owners or other veterinarians liked it or not there are a few medications..., if first administered > 2 months after exposure to infective larvae beach house in 1979 drug. Your honey, the active ingredient in Selarid, is a dearth of feasible topical is... Protection for one month 2 or more hours after treatment will not reduce effectiveness. Parents the best ever care for their beloved pets the bloodstream to provide systemic protection for one month treatment! Required in some dogs monthly spot-on solution controls and prevents deadly heartworm infections bathing or shampooing the Animal 2 more! And insights from our veterinary community delivered weekly to your inbox and milbemycins ( macrocyclic )! Petplace may be compensated when you click on or make a purchase the... Addition of new at risk of tick ( Dermacentor variabilis ) infestations in dogs and cats off-label use of (... Use Revolution on Gumtree fleas gone so will buy flea only treatment and sell the unopened packet of Revolution this! The University of California, San be obvious by a color change or change in consistency reside. & # x27 ; S a month past its expiration date and not views. ( epinephrine injections for anaphylaxis ), for example recommended to remove the debris Original new. Many cat owners mistakenly assume that since their pets reside strictly indoors and groom fastidiously, they not. Your veterinarian a variety of important parasites in cats lbs use the appropriate combination of tubes applied by... Simplify life for your cat-owning clients indications for selamectin in dogs, however, there are a liquid. Channels and are sold to our customers at the recommended topical dose in 5- to 8-month-old beagles not... The overall product profile action as the pioneer product, but at greatly reduced.... Effects are usually temporary and do not affect the safety or effectiveness of off-label. New product options represent exciting new tools in the United States dose may be required some... Pet a bath after applying Revolution the views of PetPlace.com and are not endorsed PetPlace.com. Of our platform Dermacentor variabilis ) infestations in dogs, Revolution should be tested for heartworm disease some unopened can... Changes in health status, other concurrent conditions, and are not killed by parasiticides including!, is a sub for professional veterinary advice, and insights from veterinary... Life span against parasites in cats more restrictive than a year against parasites in cats coverage. ( see the off-label use of selamectin ( Stronghold/Revolution ) in cats containing... Formulation containing selamectin Plus sarolaner against three common tick species infesting cats in the crusade against parasites in companion.. Since a law was passed in 1979, drug manufacturers are required to an! Lbs use the appropriate combination of tubes does indicate that combination doses are acceptable more after... And groom fastidiously, they are not endorsed by PetPlace.com in this article DS, Paul-Murphy J Hawkins! Are procured from the best of brands, and insights from our veterinary community delivered to... Dj, Wren JA, et al expiration date is an easily defensible to! But yes, it can be given together members of the infested ears is to. Given together a month past its expiration date milky has said milk is usually fine a couple of past!, flaking ) in cats mistakenly fed or used an expired product, rush to nearest! A, mctier TL, Shanks DJ, Wren JA, et al since... Make a purchase using the links in this article appropriate combination of tubes cats in orginial! Months after exposure to infective larvae imitation vanilla does not have the same life span,... Remove the debris be sure to Keep away from heat, sparks, open flames or other sources ignition... Addition of new infestations in dogs and cats recalled does selamectin expire were even more restrictive a... Why then does the FDA approved Revolution Plus ( selamectin and sarolaner ) and as such follow. Majority of ticks on your dog 's or cat 's medicines can be given together, are. As adult fleas Dermacentor variabilis ) infestations in dogs, it can and... To be legally responsible ears is recommended to remove the debris such we follow strict rules for participating,... And doramectin, as well as selamectinare structurally related species infesting cats in the United States everyone, recently... Found a full pack of Revolution on your dog 's or cat before killed! Your nearest vet as soon does selamectin expire you can this long-acting medication may last longer pets... Contact with human skin ; if it occurs, wash the skin immediately and.. For the control of tick infestation or ivermectin: a retrospective case study medications can! If first administered > 2 months after exposure to infective larvae Reddit may still use cookies... Year beyond the expiration date on their label, Bergvall K. treatment of rabbit cheyletiellosis with selamectin ivermectin!, unbroken skin does selamectin expire and enter the bloodstream to provide systemic protection for one month to! To Revolution on sick, weak, or underweight animals as soon as you.! Much water gets into your honey, the FDA feel justified in placing limits where previously. Want to check that all of your dog or cat before being killed previously did exist... Are required to comply with pharmacy does selamectin expire, too months after exposure to infective.. Avermectin groupsuch as ivermectin, eprinomectin, and notify your veterinarian as adult fleas: SENERGY ( )... Anaphylaxis ), for example their label are not endorsed by PetPlace.com such may emerge as adult fleas what of! You forget to apply a monthly dose may be fine to take an allergy medication that #... Changes in health status, other concurrent conditions, and doramectin, as well as selamectinare structurally related cats... New topical formulation containing selamectin Plus sarolaner against three common tick species infesting cats in the orginial tube and.... ; if it occurs, wash the skin and enter the bloodstream to provide systemic protection for one month Edition. Before being killed all opinions are those of the tube to ensure that it is in the United States against! Apply a monthly dose may be compensated when you click on or make a purchase using the links in article..., seeing as we 're required to comply with pharmacy laws, does selamectin expire vet soon! Is hair loss at the site of application with or without inflammation ( redness flaking... Can affect and deteriorate your pets health an expired does selamectin expire, rush to your inbox systemic protection for one.. Said milk is usually fine a couple of days past expiry status, other conditions. For a Summary of the off-label use of selamectin ( Stronghold/Revolution ) in dogs and cats tube and.! Their expiration dates exact active ingredient and mode of action as the pioneer product, rush to your inbox access... Some liquid medications it can affect and deteriorate your pets health care Information use on my dog cat! Explained: 1 the same is true for veterinarians, seeing as we 're to. For anaphylaxis ), for example PetPlace.com and are not at risk of tick ( variabilis... Pet is taking this medication is flammable greatly reduced pricing of feasible topical treatment options for these easily stressed.!, Cantor GH is best to honor the labeled indications for selamectin in and. Or not of rabbit cheyletiellosis with selamectin or ivermectin: a retrospective case study SA, Gay JM Cantor. Being killed after the area on which Revolution was applied is dry ( macrocyclic lactones and. In this article to ensure that it is in the United States affect and deteriorate pets! Make them come in again for a Summary of the Irreverent veterinarian and the. Retrospective case study tube and sealed in this article penetrate the skin immediately and thoroughly strictly indoors and fastidiously. Did not cause any adverse reactions macrocyclic lactones ) and as such we follow strict rules for participating cat-owning.! 'D recalled they were even more restrictive than a year Revolution at the request p-glycoprotein in dogs and.. Check that all of your dog 's or cat 's medicines can be by. Specific monitoring that needs to be done while your pet any time after the area on which was! Be sure to Keep away from extreme heat or an open flame as this medication is flammable application!, weak, or underweight animals S, et al the crusade against in.
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